A Polarized Temporal Network Model to Study the Spread of Recurrent Epidemic Diseases in a Partially Vaccinated Population (preprint)

Motivated by massive outbreaks of COVID-19 that occurred even in populations with high vaccine uptake, we propose a novel multi-population temporal network model for the spread of recurrent epidemic diseases. We study the effect of human behavior, testing, and vaccination campaigns on the control of local outbreaks and infection prevalence. Our modeling framework decouples the vaccine effectiveness in protecting against transmission and the development of severe symptoms. Furthermore, the framework accounts for the polarizing effect of the decision to vaccinate and captures homophily, i.e., the tendency of people to interact with like-minded individuals. By means of a mean-field approach, we analytically derive the epidemic threshold. Our theoretical results suggest that, while vaccination campaigns reduce pressure on hospitals, they might facilitate resurgent outbreaks, highlighting the key role that testing campaigns may have in eradicating the disease. Numerical simulations are then employed to confirm and extend our theoretical findings to more realistic scenarios. Our numerical and analytical results agree that vaccination is not sufficient to achieve full eradication, without employing massive testing campaigns or relying on the population's responsibility. Furthermore, we show that homophily plays a critical role in the control of local outbreaks, highlighting the peril of a polarized network structure.

Modelling the Effect of Vaccination and Human Behaviour on the Spread of Epidemic Diseases on Temporal Networks (preprint)

Motivated by the increasing number of COVID-19 cases that have been observed in many countries after the vaccination and relaxation of non-pharmaceutical interventions, we propose a mathematical model on time-varying networks for the spread of recurrent epidemic diseases in a partially vaccinated population. The model encapsulates several realistic features, such as the different effectiveness of the vaccine against transmission and development of severe symptoms, testing practices, the possible implementation of non-pharmaceutical interventions to reduce the transmission, isolation of detected individuals, and human behaviour. Using a mean-field approach, we analytically derive the epidemic threshold of the model and, if the system is above such a threshold, we compute the epidemic prevalence at the endemic equilibrium. These theoretical results show that precautious human behaviour and effective testing practices are key toward avoiding epidemic outbreaks. Interestingly, we found that, in many realistic scenarios, vaccination is successful in mitigating the outbreak by reducing the prevalence of seriously ill patients, but it could be a double-edged sword, whereby in some cases it might favour resurgent outbreaks, calling for higher testing rates, more cautiousness and responsibility among the population, or the reintroduction of non-pharmaceutical interventions to achieve complete eradication.

Predicting the effects of waning vaccine immunity against COVID-19 through high-resolution agent-based modeling (preprint)

The potential waning of the vaccination immunity to COVID-19 could pose threats to public health, as it is tenable that the timing of such waning would synchronize with the near-complete restoration of normalcy. Should also testing be relaxed, we might witness a resurgent COVID-19 wave in winter 2021/2022. In response to this risk, an additional vaccine dose, the booster shot, is being administered worldwide. In a projected study with an outlook of six months, we explore the interplay between the rate at which boosters are distributed and the extent to which testing practices are implemented, using a highly granular agent-based model tuned on a medium-sized U.S. town. Theoretical projections indicate that the administration of boosters at the rate at which the vaccine is currently administered could yield a severe resurgence of the pandemic. Projections suggest that the peak levels of mid spring 2021 in the vaccination rate may prevent such a scenario to occur, although exact agreement between observations and projections should not be expected due to continuously evolving nature of the pandemics. Our study highlights the importance of testing, especially to detect asymptomatic individuals in the near future, as the release of the booster reaches full speed.

Optimal policy design to mitigate epidemics on networks using an SIS model (preprint)

Understanding how to effectively control an epidemic spreading on a network is a problem of paramount importance for the scientific community. The ongoing COVID-19 pandemic has highlighted the need for policies that mitigate the spread, without relying on pharmaceutical interventions, that is, without the medical assurance of the recovery process. These policies typically entail lockdowns and mobility restrictions, having thus nonnegligible socio-economic consequences for the population. In this paper, we focus on the problem of finding the optimum policies that "flatten the epidemic curve" while limiting the negative consequences for the society, and formulate it as a nonlinear control problem over a finite prediction horizon. We utilize the model predictive control theory to design a strategy to effectively control the disease, balancing safety and normalcy. An explicit formalization of the control scheme is provided for the susceptible--infected--susceptible epidemic model over a network. Its performance and flexibility are demonstrated by means of numerical simulations.

A multi-layer network model to assess school opening policies during the COVID-19 vaccination campaign (preprint)

We propose a multi-layer network model for the spread of COVID-19 that accounts for interactions within the family, between schoolmates, and casual contacts in the population. We utilize the proposed model-calibrated on epidemiological and demographic data-to investigate current questions concerning the implementation of non-pharmaceutical interventions (NPIs) during the vaccination campaign. Specifically, we consider scenarios in which the most fragile population has already received the vaccine, and we focus our analysis on the role of schools as drivers of the contagions and on the implementation of targeted intervention policies oriented to children and their families. We perform our analysis by means of a campaign of Monte Carlo simulations. Our findings suggest that, in a phase with NPIs enacted but in-person education, children play a key role in the spreading of COVID-19. Interestingly, we show that children's testing might be an important tool to flatten the epidemic curve, in particular when combined with enacting temporary online education for classes in which infected students are detected. Finally, we test a vaccination strategy that prioritizes the members of large families and we demonstrate its good performance. We believe that our modeling framework and our findings could be of help for public health authorities for planning their current and future interventions, as well as to increase preparedness for future epidemic outbreaks.

Analysis, Prediction, and Control of Epidemics: A Survey from Scalar to Dynamic Network Models (preprint)

During the ongoing COVID-19 pandemic, mathematical models of epidemic spreading have emerged as powerful tools to produce valuable predictions of the evolution of the pandemic, helping public health authorities decide which intervention policies should be implemented. The study of these models -- grounded in the systems theory and often analyzed using control-theoretic tools -- is an extremely important research area for many researchers from different fields, including epidemiology, engineering, physics, mathematics, computer science, sociology, economics, and management. In this survey, we review the history and present the state of the art in the modeling, analysis, and control of epidemic dynamics. We discuss different approaches to epidemic modeling, either deterministic or stochastic, ranging from the first implementations of scalar systems of differential equations to describing the epidemic spreading at the population level, and to more recent models on dynamic networks, which capture the spatial spread and the time-varying nature of human interactions.

High-resolution agent-based modeling of COVID-19 spreading in a small town (preprint)

Amid the ongoing COVID-19 pandemic, public health authorities and the general population are striving to achieve a balance between safety and normalcy. Ever changing conditions call for the development of theory and simulation tools to finely describe multiple strata of society while supporting the evaluation of "what-if" scenarios. Particularly important is to assess the effectiveness of potential testing approaches and vaccination strategies. Here, an agent-based modeling platform is proposed to simulate the spreading of COVID-19 in small towns and cities, with a single-individual resolution. The platform is validated on real data from New Rochelle, NY -- one of the first outbreaks registered in the United States. Supported by expert knowledge and informed by reported data, the model incorporates detailed elements of the spreading within a statistically realistic population. Along with pertinent functionality such as testing, treatment, and vaccination options, the model accounts for the burden of other illnesses with symptoms similar to COVID-19. Unique to the model is the possibility to explore different testing approaches -- in hospitals or drive-through facilities -- and vaccination strategies that could prioritize vulnerable groups. Decision making by public authorities could benefit from the model, for its fine-grain resolution, open-source nature, and wide range of features.

Modelling and predicting the effect of social distancing and travel restrictions on COVID-19 spreading (preprint)

To date, the only effective means to respond to the spreading of COVID-19 pandemic are non-pharmaceutical interventions (NPIs), which entail policies to reduce social activity and mobility restrictions. Quantifying their effect is difficult, but it is key to reduce their social and economical consequences. Here, we introduce a meta-population model based on temporal networks, calibrated on the COVID-19 outbreak data in Italy and apt to evaluate the outcomes of these two types of NPIs. Our approach combines the advantages of granular spatial modelling of meta-population models with the ability to realistically describe social contacts via activity-driven networks. We provide a valuable framework to assess the viability of different NPIs, varying with respect to their timing and severity. Results suggest that the effects of mobility restrictions largely depend on the possibility to implement timely NPIs in the early phases of the outbreak, whereas activity reduction policies should be prioritised afterwards.

Modelling collective decision-making during epidemics (preprint)

The outcome of an epidemic outbreak can be critically shaped by the collective behavioural response of the population. Likewise, individual decision-making is highly influenced by the overwhelming pressure of epidemic spreading. However, existing models lack the ability to capture this complex interdependence over the entire course of the epidemic. We introduce a novel parsimonious network model, grounded in evolutionary game theory, in which decision-making and epidemics co-evolve, shaped by an interplay of factors mapped onto a minimal set of model parameters ---including government-mandated interventions, socio-economic costs, perceived infection risks and social influences. This interplay gives rise to a range of characteristic phenomena that can be captured within this general framework, such as sustained periodic outbreaks, multiple epidemic waves, or prompt behavioural response ensuring a successful eradication of the disease. The model's potentialities are demonstrated by three case studies based on real-world gonorrhoea, 1918--19 Spanish flu and COVID-19.